Defining and identifying causal intervention effects for transmissible infectious disease outcomes is challenging because a treatment – such as a vaccine – given to one individual may affect the infection outcomes of others. Epidemiologists have proposed causal estimands to quantify effects of interventions under contagion using a two-person partnership model. These simple conceptual models have helped researchers develop causal estimands relevant to clinical evaluation of vaccine effects. However, many of these partnership models are formulated under structural assumptions that preclude realistic (...) infectious disease transmission dynamics, limiting their conceptual usefulness in defining and identifying causal treatment effects in empirical intervention trials. In this paper, we propose causal intervention effects in two-person partnerships under arbitrary infectious disease transmission dynamics, and give nonparametric identification results showing how effects can be estimated in empirical trials using time-to-infection or binary outcome data. The key insight is that contagion is a causal phenomenon that induces conditional independencies on infection outcomes that can be exploited for the identification of clinically meaningful causal estimands. These new estimands are compared to existing quantities, and results are illustrated using a realistic simulation of an HIV vaccine trial. (shrink)

Themistokles was ostracized in the late 470's, probably in spring 471 or 470; if we are to believe Thucydides, he did not write to Artaxerxes in Persia until 465 at the earliest. In some way or other his stay in Argos and visits to the rest of the Peloponnese, his wanderings in northern Greece, and his delay in Asia Minor must be extended to fill this gap of at least five years. There is evidence of a sort, there are arguments (...) good and bad for the lengthening or shortening of any of these episodes, but none of this evidence or argument is conclusive. Between 470 and 465 no event in Themistokles' life can be securely dated; there is no fixed chronological pattern into which a reconstruction of the political history of Athens and the Peloponnese during these years must fit. Since the reconstruction which I attempt here is itself based on evidence which is far from adequate, plausibility is the most that can be claimed for it or for the chronological scheme which I infer from it. (shrink)

The average educated Greek, I am sure, knew the early history of Greece as well as the average educated European knows the history of modern Europe, and could no more separate Theopompos from the first Messenian War or put Pheidon after Kypselos than we can separate Wellington from Waterloo or make Frederick the Great follow Napoleon. The professional historian, antiquarian, or chronographer would know much more, but could readily distort what he knew in trying to impose some theoretical pattern on (...) the past. Where so many of our sources are theoretical and when they survive in fragments which are rarely substantial enough to show in detail the theory on which they worked, it is not easy to see through to the core of Greek belief on which they were based. But facts there were and in the main it was from them that the theorizing started. (shrink)

In his admirable commentary, Jeffrey Henderson notes the significance of posture and of physical setting. He does not remark that the statue of Leaina near to which Lysistrata and Kalonike are standing on the Akropolis was intimately tied to the obscure story of the later years in the Athenian tyranny. With minor variations of detail or colour the story was that Leaina, a hetaira beloved of Harmodios or Aristogeiton, had been tortured by Hippias after the murder of Hipparchos but, brave (...) girl, had preferred to die than say yes, or indeed say anything. She bit out her tongue. The Athenians set up a bronze lioness, the work of Amphikrates, to commemorate her martyrdom. (shrink)

Immanuel Kant was a German philosopher. He is a central figure of modern philosophy, and set the terms by which all subsequent thinkers have had to grapple. He argued that human perception structures natural laws, and that reason is the source of morality. His thought continues to hold a major influence in contemporary thought, especially in fields such as metaphysics, epistemology, ethics, political philosophy, and aesthetics.

This chapter contains sections titled: The Aesthetic Appreciating Nature Skepticism Regarding Aesthetic Nature Aesthetics and the Concept of Nature.

One of the most compelling questions still unanswered in neuroscience is how consciousness arises. In this article, we examine visual processing, the parietal lobe, and contralateral neglect syndrome as a window into consciousness and how the brain functions as the mind and we introduce a mechanism for the processing of visual information and its role in consciousness. We propose that consciousness arises from integration of information from throughout the body and brain by the thalamus and that the thalamus reimages visual (...) and other sensory information from throughout the cortex in a default three-dimensional space in the mind. We further suggest that the thalamus generates a dynamic default three-dimensional space by integrating processed information from corticothalamic feedback loops, creating an infrastructure that may form the basis of our consciousness. Further experimental evidence is needed to examine and support this hypothesis, the role of the thalamus, and to further elucidate the mechanism of consciousness. (shrink)

The Global Workspace Theory and Information Integration Theory are two of the most currently accepted consciousness models; however, these models do not address many aspects of conscious experience. We compare these models to our previously proposed consciousness model in which the thalamus fills-in processed sensory information from corticothalamic feedback loops within a proposed 3D default space, resulting in the recreation of the internal and external worlds within the mind. This 3D default space is composed of all cells of the body, (...) which communicate via gap junctions and electrical potentials to create this unified space. We use 3D llustrations to explain how both visual and non-visual sensory information may be filled-in within this dynamic space, creating a unified seamless conscious experience. This neural sensory memory space is likely generated by baseline neural oscillatory activity from the default mode network, other salient networks, brainstem, and reticular activating system. (shrink)

Intercellular signaling plays an important role in spatially regulated developmental processes. Myxococcus xanthus C signal transmission during fruiting body formation requires motile, densely packed, well aligned cells. tThe fruiting body consists of two domains: an outer domain which has densely packed, well aligned, motile cells: and an inner domain of more loosely packed, non‐motile, sporulating cells. The two domains are characterized by different patterns of C‐dependent gene expression, which begins in the outer domain where C‐signaling is most efficient, and reaches (...) its maximum in the inner domain. These domains may be maintained by a dynamic mechanism which relies on passive transport of the sporulating cells from the outer domain, where sporulation is initiated, to the inner domain by the motile cells in the outer domain. (shrink)

The complex activity of the human brain makes it difficult to get a big picture of how the brain works and functions as the mind. We examine pertinent studies, as well as evolutionary and embryologic evidence to support our theoretical model consisting of separate but interactive layers of human neural activity. The most basic layer involves default mode network (DMN)activity and cardiorespiratory oscillations. We propose that these oscillations support other neural activity and cognitive processes. The second layer involves limbic system (...) activity accompanied by corresponding changes in cardiorespiratory oscillations. The third layer consists of corticothalamic processing and involves higher cortical functions including awareness, cognition,and consciousness. These layers interact to form the complex neural activity of the human brain. Examining the origins and relationships of various neural and physiologic oscillations may provide better understanding of human neurophysiology and consciousness. (shrink)